Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer's disease: A population-based nested case-control study.

ABSTRACT:

Introduction

Our population-based study assessed whether clinically apparent Helicobacter pylori infection (CAHPI) is associated with the risk of Alzheimer's disease (AD).

Methods

We assembled a population-based cohort of all dementia-free subjects in the United Kingdom's Clinical Practice Research Datalink (UK CPRD), aged ≥50 years (1988-2017). Using a nested case-control approach, we matched each newly developed case of AD with 40 controls. Conditional logistic regression estimated odds ratios (ORs) with 95% confidence intervals (CIs) of AD associated with CAHPI compared with no CAHPI during ≥2 years before the index date. We also used salmonellosis as a negative control exposure.

Results

Among 4,262,092 dementia-free subjects, 40,455 developed AD after a mean 11 ye

SUBMITTER: Douros A 

PROVIDER: S-EPMC10984501 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature