Prior human polyomavirus and papillomavirus infection and incident lung cancer: a nested case-control study.

ABSTRACT:

Purpose

To test whether infection with select human polyomaviruses (HPyV) and human papillomaviruses (HPV) is associated with incident lung cancer.

Methods

We performed a nested case-control study, testing serum from the carotene and retinol efficacy trial, conducted 1985-2005, for antibodies to Merkel cell (MCV), KI (KIV), and WU (WUV) HPyVs as well as to six high-risk and two low-risk HPV types. Incident lung cancer cases (n = 200) were frequency-matched with controls (n = 200) on age, enrollment and blood draw dates, intervention arm assignment, and the number of serum freeze/thaw cycles. Sera were tested using multiplex liquid bead microarray antibody assays. We used logistic regression to assess the association between HPyV and HPV antibodies and lung cancer.

Results

SUBMITTER: Colombara DV 

PROVIDER: S-EPMC4628600 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature