Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection.

ABSTRACT:

Introduction

We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States.

Methods

Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires.

Results

Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk s

SUBMITTER: Goguet E 

PROVIDER: S-EPMC10985347 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature