Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice.

ABSTRACT:

Background

Cognitive deficits and behavioral disorders such as anxiety and depression are common manifestations of Alzheimer's disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques and improve cognitive disorders. AD, anxiety, and depression are all associated with microglial inflammation. However, whether TSA could attenuate anxiety- and depression-like behaviors in APP/PS1 mice through anti-inflammatory signaling is still unclearly.

Methods

In the present study, all mice were subjected to the open field, elevated plus maze, and forced swim tests to assess anxiety- and depression-related behaviors after TSA administration. To understand the possible mechanisms underlying the behavioral effects observed, CST7

SUBMITTER: Su Q 

PROVIDER: S-EPMC10987769 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature