Inhibition of malaria and babesiosis parasites by putative red blood cell targeting small molecules.

ABSTRACT:

Background

Chemotherapies for malaria and babesiosis frequently succumb to the emergence of pathogen-related drug-resistance. Host-targeted therapies are thought to be less susceptible to resistance but are seldom considered for treatment of these diseases.

Methods

Our overall objective was to systematically assess small molecules for host cell-targeting activity to restrict proliferation of intracellular parasites. We carried out a literature survey to identify small molecules annotated for host factors implicated in Plasmodium falciparum infection. Alongside P. falciparum, we implemented in vitro parasite susceptibility assays also in the zoonotic parasite Plasmodium knowlesi and the veterinary parasite Babesia divergens. We additionally

SUBMITTER: Groomes PV 

PROVIDER: S-EPMC10988762 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature