Chitobiose exhibited a lipid-lowering effect in ob/ob^-/- mice via butyric acid enrolled liver-gut crosstalk.

ABSTRACT: Chitobiose (COS₂) efficiently lowers lipids in vivo and facilitates butyric acid enrichment during human fecal fermentation. However, whether COS₂ can interact with butyric acid to generate a hypolipidemic effect remains unclear. This study examined the hypolipidemic mechanism of COS₂ involving butyric acid, which could alleviate non-alcoholic fatty liver disease (NAFLD). The results revealed that COS₂ administration modulated the β-oxidation pathway in the liver and restructured the short chain fatty acids in the fecal of ob/ob^-/- mice. Moreover, the hypolipidemic effect of COS₂ and its specific accumulated metabolite butyric acid was verified in sodium oleate-induced HepG2 cells. Butyric acid was more effective to reverse

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC10991647 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature