A general exposome factor explains individual differences in functional brain network topography and cognition in youth.

ABSTRACT: Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping of childhood environments, we can now build upon prior studies that have considered relationships between one or a handful of environmental and neuroimaging features at a time. Here, we characterize the combined effects of hundreds of inter-connected and co-occurring features of a child's environment ("exposome") and investigate associations with each child's unique, multidimensional pattern of functional brain network organization ("functional topography") and cognition. We apply data-driven computational models to measure the exposome and define personalized functional brain networks in pre-registered analyses. Across match

SUBMITTER: Keller AS 

PROVIDER: S-EPMC11004064 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature