Clinical Outcomes of Small Cell Carcinoma of the Genitourinary Tract and the Prognostic Significance of the Tumor Immune Microenvironment.

ABSTRACT:

Purpose

Small cell carcinoma of the genitourinary tract (GU SCC) is a rare disease with a poor prognosis. There are only limited treatment options due to insufficient understanding of the disease. In this study, we analyzed the clinical outcomes of patients with GU SCC and their association with the tumor immune phenotype.

Materials and methods

Patients diagnosed with GU SCC were included. Survival outcomes according to the primary location (prostate and non-prostate) and stages (limited disease [LD] and extensive disease [ED]) were analyzed. We performed multiplex immunohistochemistry (IHC) in non-prostate SCC patients and analyzed the immune cell population.

Results

A total of 77 patients were included in this study. Their median age was 71 years, 67 patients (87.0%

SUBMITTER: Hyung J 

PROVIDER: S-EPMC11016647 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature