Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study.

ABSTRACT:

Background

Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of all-cause and cause-specific dementia.

Methods

We conducted a prospective study with 403,506 participants from the UK Biobank. Outcomes included all-cause dementia, Alzheimer's disease, and vascular dementia. Multivariable Cox proportional hazards models were used for analyses.

Results

155,068 (38.4%) participants had MAFLD, and 111,938 (27.7%) had MASLD at baseline. During a median follow-up of 13.7 years, 5,732 participants developed dementia (2,355 Alzheimer's disease and

SUBMITTER: Bao X 

PROVIDER: S-EPMC11201326 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature