Synergistic Effect of SiO₂ and Fe₃O₄ Nanoparticles in Autophagy Modulation.

ABSTRACT: Rapid advancements in nanotechnology have expanded its applications and synergistic impact on modern nanosystems. The comprehensive assessment of nanomaterials' safety for human exposure has become crucial and heightened. In addition to the characterization of cell proliferation and apoptosis, probing the implication of autophagy is vital for understanding the ramification of nanomaterials. Hence, HEK-293 kidney cells were employed to understand the changes in induction and perturbation of autophagy in cells by iron oxide (Fe₃O₄) and silica (SiO₂) nanoparticles. Interestingly, Fe₃O₄ worked as a potent modulator of the autophagy process through its catalytic performance, which can develop better than that of SiO₂ nanoparticle

SUBMITTER: Nanda SS 

PROVIDER: S-EPMC11207018 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature