Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats.

ABSTRACT:

Background

Breeding polled goats is a welfare-friendly approach for horn removal in comparison to invasive methods. To gain a comprehensive understanding of the genetic basis underlying polledness in goats, we conducted whole-genome sequencing of 106 Xinong Saanen dairy goats, including 33 horned individuals, 70 polled individuals, and 3 polled intersexuality syndrome (PIS) individuals.

Methods

The present study employed a genome-wide association study (GWAS) and linkage disequilibrium (LD) analysis to precisely map the genetic locus underlying the polled phenotype in goats.

Results

The analysis conducted in our study revealed a total of 320 genome-wide significant single nucleotide polymorphisms (SNPs) associated with the horned/polled phenotype in goats. These SNPs

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11218382 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature