Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.
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SUBMITTER: Holl D
PROVIDER: S-EPMC11239523 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.
Holl Daniel D Hau Wing Fung WF Julien Anais A Banitalebi Shervin S Kalkitsas Jannis J Savant Soniya S Llorens-Bobadilla Enric E Herault Yann Y Pavlovic Guillaume G Amiry-Moghaddam Mahmood M Dias David Oliveira DO Göritz Christian C
Nature neuroscience 20240607 7
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin of scar-forming fibroblasts is unclear. Here, we show that stromal fibroblasts forming the fibrotic scar derive from two populations of perivascular cells after spinal cord injury (SCI) in adult mice of both sexes. We anatomically and transcriptionally identify the two cell populations as pericytes and perivascular fibroblasts. Fibroblasts and peric ...[more]
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