Dataset Information

Association of spermidine plasma levels with brain aging in a population-based study.

ABSTRACT:

Introduction

Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD).

Methods

Data from 659 participants (age range: 21-81 years) of the population-based Study of Health in Pomerania TREND were included. We investigated the association between spermidine plasma levels and markers of brain aging (hippocampal volume, AD score, global cortical thickness [CT], and white matter hyperintensities [WMH]).

Results

Higher spermidine levels were significantly associated with lower hippocampal volume (ß = -0.076; 95% confidence interval [CI]: -0.13 to -0.02; q = 0.026), higher AD score (ß = 0.118; 95% CI: 0.05 to 0.19; q = 0.006), lower global CT (ß = -0.104; 95% CI: -0.17 to -0.04; q = 0.014), but not WMH volume. Sensitivity analysis revealed no substantial changes after excluding participants with cancer, depression, or hemolysis.

Discussion

Elevated spermidine plasma levels are associated with advanced brain aging and might serve as potential early biomarker for AD and vascular brain pathology.

SUBMITTER: Wortha SM

PROVIDER: S-EPMC11246659 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Publications

Association of spermidine plasma levels with brain aging in a population-based study.

Wortha Silke M SM Frenzel Stefan S Bahls Martin M Habes Mohamad M Wittfeld Katharina K Van der Auwera Sandra S Bülow Robin R Zylla Stephanie S Friedrich Nele N Nauck Matthias M Völzke Henry H Grabe Hans J HJ Schwarz Claudia C Flöel Agnes A

Alzheimer's & dementia : the journal of the Alzheimer's Association 20221102 5

<h4>Introduction</h4>Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD).<h4>Methods</h4>Data from 659 participants (age range: 21-81 years) of the population-based Study of Health in Pomerania TREND were included. We investigated the association between spermidine plasma levels and markers of brain aging (hippocampal volume, AD score, global cortical thickness [CT], and white matter hyperinten ...[more]

PMID: 36321615

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Project description:ContextThe adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes beta-amyloid clearance, and improves memory function in animal models of aging and Alzheimer disease (AD).ObjectiveTo relate baseline circulating leptin concentrations in a community-based sample of individuals without dementia to incident dementia and AD during follow-up and magnetic resonance imaging (MRI) measures of brain aging in survivors.Design, setting, and participantsProspective study of plasma leptin concentrations measured in 785 persons without dementia (mean [SD] age, 79 [5] years; 62% female), who were in the Framingham original cohort at the 22nd examination cycle (1990-1994). A subsample of 198 dementia-free survivors underwent volumetric brain MRI between 1999 and 2005, approximately 7.7 years after leptin was assayed. Two measures of brain aging, total cerebral brain volume and temporal horn volume (which is inversely related to hippocampal volume) were assessed.Main outcome measureIncidence of dementia and AD during follow-up until December 31, 2007.ResultsDuring a median follow-up of 8.3 years (range, 0-15.5 years), 111 participants developed incident dementia; 89 had AD. Higher leptin levels were associated with a lower risk of incident dementia and AD in multivariable models (hazard ratio per 1-SD increment in log leptin was 0.68 [95% confidence interval, 0.54-0.87] for all-cause dementia and 0.60 [95% confidence interval, 0.46-0.79] for AD). This corresponds to an absolute AD risk over a 12-year follow-up of 25% for persons in the lowest quartile (first quartile) vs 6% for persons in the fourth quartile of sex-specific leptin levels. In addition, a 1-SD elevation in plasma leptin level was associated with higher total cerebral brain volume and lower temporal horn volume, although the association of leptin level with temporal horn volume did not reach statistical significance.ConclusionCirculating leptin was associated with a reduced incidence of dementia and AD and with cerebral brain volume in asymptomatic older adults.

Dataset Information

Association of spermidine plasma levels with brain aging in a population-based study.

Introduction

Methods

Results

Discussion

Publications

Association of spermidine plasma levels with brain aging in a population-based study.

Similar Datasets

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