Inhibitory effect of Lonicera japonica flos on Streptococcus mutans biofilm and mechanism exploration through metabolomic and transcriptomic analyses.

ABSTRACT:

Introduction

Streptococcus mutans was the primary pathogenic organism responsible for dental caries. Lonicera japonica flos (LJF) is a traditional herb in Asia and Europe and consumed as a tea beverage for thousands of years.

Methods

The inhibitory effect and mechanism of LJF on biofilm formation by S. mutans was investigated. The active extracts of LJF were validated for their inhibitory activity by examining changes in surface properties such as adherence, hydrophobicity, auto-aggregation abilities, and exopolysaccharides (EPS) production, including water-soluble glucan and water-insoluble glucan.

Results and discussion

LJF primarily inhibited biofilm formation through the reduction of EPS production, resulting in alterations in cell surface cha

SUBMITTER: Wang L 

PROVIDER: S-EPMC11256199 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature