Associations of amyloid-β oligomers and plaques with neuropathology in the App ^NL-G-F mouse.

ABSTRACT: Amyloid-β pathology and neurofibrillary tangles lead to glial activation and neurodegeneration in Alzheimer's disease. In this study, we investigated the relationships between the levels of amyloid-β oligomers, amyloid-β plaques, glial activation and markers related to neurodegeneration in the App ^NL-G-F triple mutation mouse line and in a knock-in line homozygous for the common human amyloid precursor protein (App ^hu mouse). The relationships between neuropathological features were characterized with immunohistochemistry and imaging mass cytometry. Markers assessing human amyloid-β proteins, microglial and astrocytic activation and neuronal and synaptic densities were used in mice between 2.5 and 12 months of age. We found that amyloid-β oligomers were

SUBMITTER: Tang J 

PROVIDER: S-EPMC11258573 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature