Pilot Evaluation of S-(3-[¹⁸F]Fluoropropyl)-D-Homocysteine and O-(2-[¹⁸F]Fluoroethyl)-D-Tyrosine as Bacteria-Specific Radiotracers for PET Imaging of Infection.

ABSTRACT:

Purpose

There is currently no ideal radiotracer for imaging bacterial infections. Radiolabelled D-amino acids are promising candidates because they are actively incorporated into the peptidoglycan of the bacterial cell wall, a structural feature which is absent in human cells. This work describes fluorine-18 labelled analogues of D-tyrosine and D-methionine, O-(2-[¹⁸F]fluoroethyl)-D-tyrosine (D-[¹⁸F]FET) and S-(3-[¹⁸F]fluoropropyl)-D-homocysteine (D-[¹⁸F]FPHCys), and their pilot evaluation studies as potential radiotracers for imaging bacterial infection.

Procedures

D-[¹⁸F]FET and D-[¹⁸F]FPHCys were prepared in classical fluorination-deprotection reactions, and their uptake in Staphylococcus aureus and Pseudom

SUBMITTER: Betts HM 

PROVIDER: S-EPMC11282134 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature