Dataset Information

White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.

ABSTRACT:

Introduction

Girls and boys presenting disruptive behavior disorders (DBDs) display differences in white matter microstructure (WMM) relative to typically developing (TD) sex-matched peers. Boys with DBDs are at increased risk for traumatic brain injuries (TBIs), which are also known to impact WMM. This study aimed to disentangle associations of WMM with DBDs and TBIs.

Methods

The sample included 673 children with DBDs and 836 TD children, aged 9-10, from the Adolescent Brain Cognitive Development Study. Thirteen white matter bundles previously associated with DBDs were the focus of study. Analyses were undertaken separately by sex, adjusting for callous-unemotional traits (CU), attention-deficit hyperactivity disorder (ADHD), age, pubertal stage, IQ, ethnicity, and family income.

Results

Among children without TBIs, those with DBDs showed sex-specific differences in WMM of several tracts relative to TD. Most differences were associated with ADHD, CU, or both. Greater proportions of girls and boys with DBDs than sex-matched TD children had sustained TBIs. Among girls and boys with DBDs, those who had sustained TBIs compared to those not injured, displayed WMM alterations that were robust to adjustment for all covariates. Across most DBD/TD comparisons, axonal density scores were higher among children presenting DBDs.

Discussion

In conclusion, in this community sample of children, those with DBDs were more likely to have sustained TBIs that were associated with additional, sex-specific, alterations of WMM. These additional alterations further compromise the future development of children with DBDs.

SUBMITTER: Guberman GI

PROVIDER: S-EPMC11295658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.

Guberman Guido I GI Theaud Guillaume G Hawes Samuel W SW Ptito Alain A Descoteaux Maxime M Hodgins Sheilagh S

Frontiers in neuroscience 20240719

<h4>Introduction</h4>Girls and boys presenting disruptive behavior disorders (DBDs) display differences in white matter microstructure (WMM) relative to typically developing (TD) sex-matched peers. Boys with DBDs are at increased risk for traumatic brain injuries (TBIs), which are also known to impact WMM. This study aimed to disentangle associations of WMM with DBDs and TBIs.<h4>Methods</h4>The sample included 673 children with DBDs and 836 TD children, aged 9-10, from the Adolescent Brain Cogn ...[more]

PMID: 39099631

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Dataset Information

White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.

Introduction

Methods

Results

Discussion

Publications

White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.

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