A Mendelian randomization study investigating causal links between gut microbiota or metabolites and chronic hepatitis B.

ABSTRACT:

Objective

This study aimed to explore the potential causal relationship between the gut microbiota and/or its metabolites and the progression of chronic hepatitis B (CHB).

Method

The gut microbiota was used as the exposure factor. The training set exposure data were obtained from the China Nucleotide Sequence Archive (CNSA). Genome-wide association study (GWAS) data from Asia were used as the outcome variables. Outcome data for both the training and validation sets were sourced from the GWAS Catalog database. A dual-sample Mendelian randomization approach was used to analyze the causal relationships, with the inverse variance-weighted method serving as the main analytical strategy. Sensitivity analysis was conducted to assess the robustness of Mendelian randomization analysi

SUBMITTER: Xing T 

PROVIDER: S-EPMC11303287 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature