Age at first sexual intercourse, age at menarche, and age at menopause: a mendelian randomization study on lung cancer risk.

ABSTRACT:

Background

There is increasing evidence that sex hormones are involved in the development of lung cancer, but the correlation between the reproductive behavior that changes sex hormone levels and lung cancer is not yet clear. Many previous studies have investigated the association between reproductive factors and lung cancer risk, but the results have been inconsistent. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis to explore the potential relationship between age at first sexual intercourse (AFS), age at menarche, and age at menopause, and lung cancer.

Methods

We performed a MR analysis of the data from the genome-wide association study (GWAS) of European ancestry to evaluate the independent effects of three reproductive behaviors on lung cancer

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11304150 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature