Age at first birth, age at menopause, and risk of ovarian cyst: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Increasing observational studies have indicated that hormonal reproductive factors were associated with ovarian cyst, a common gynecological disease. A two-sample Mendelian randomization (MR) was carried out by investigating the causality of reproductive factors including age at first birth (AFB), age at natural menopause (ANM), and age at menarche (AAM), and the risk of ovarian cyst (OC).

Method

Summary statistics were collected from a large genome-wide association study (GWAS), and we used a two-sample MR study to clarify the causal association between the exposure of AFB (N = 542,901), ANM (N = 69,360), and AAM (N = 29,346) and the outcome of the OC (N _case = 20,750, N _control = 107,564). We separately se

SUBMITTER: Su Q 

PROVIDER: S-EPMC10794498 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature