Defining and Assessing International Classification of Disease Suicidality Phenotypes for Genetic Studies.

ABSTRACT:

Background

Suicidality, including suicidal ideation (SI), attempt (SA), and death (SD), represents complex and partially overlapping phenotypes. This complexity contributes to study population heterogeneity in suicidality research, impeding replication efforts and data consolidation by research consortia. The standardization of suicidality definitions would help but has been insufficiently addressed in existing literature. Here, the Suicide Workgroup of the Psychiatric Genomics Consortium (PGC) provides International Classification of Disease (ICD) definitions, a critical real-world data source, for SA and SI.

Methods

The PGC Suicide Workgroup used published definitions coupled with expert consensus to develop ICD lists to serve as suicidality phenotype definitions. One SI a

SUBMITTER: Monson ET 

PROVIDER: S-EPMC11312669 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature