Intrinsic risk factors for alpha-gal syndrome in a case-control study, 2019 to 2020.

ABSTRACT:

Background

Alpha-gal syndrome (AGS) is an allergy to galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in most mammals. Evidence indicates that AGS develops after a tick bite, and in the United States, AGS is most associated with bites from Amblyomma americanum (lone star tick); however, not all persons bitten by ticks develop clinical AGS.

Objective

To investigate intrinsic risk factors associated with the development of AGS.

Methods

We performed a case-control study among adults presenting for diagnosis or management of AGS at an allergy clinic in North Carolina during 2019 to 2020 and compared them with controls enrolled from 2 nearby internal medicine clinics. A questionnaire gathered epidemiologic and tick exposure data, and blood was obtained for alpha

SUBMITTER: Taylor ML 

PROVIDER: S-EPMC11318600 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature