Alterations of Placental Sodium in Preeclampsia: Trophoblast Responses.

ABSTRACT:

Background

Evidence suggests that increasing salt intake in pregnancy lowers blood pressure, protecting against preeclampsia. We hypothesized that sodium (Na⁺) evokes beneficial placental signals that are disrupted in preeclampsia.

Methods

Blood and urine were collected from nonpregnant women of reproductive age (n=26) and pregnant women with (n=50) and without (n=55) preeclampsia, along with placental biopsies. Human trophoblast cell lines and primary human trophoblasts were cultured with varying Na⁺ concentrations.

Results

Women with preeclampsia had reduced placental and urinary Na⁺ concentrations, yet increased urinary angiotensinogen and reduced active renin, aldosterone concentrations, and osmotic response signal TonEBP (tonicity

SUBMITTER: Mistry HD 

PROVIDER: S-EPMC11319085 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature