Establishment and verification of chromium and cobalt concentrations in joint fluids from a reference population.

ABSTRACT: This study aims to establish joint fluid reference levels for Chromium (Cr) and Cobalt (Co) in a reference population of available fluid types. Method performance was evaluated on an existing urine matrix calibration method using inductively coupled plasma-mass spectrometry. Method performance characteristics, including intra- and inter-assay imprecision, accuracy, linearity, AMR (analytical measurement range), sensitivity, and carryover were determined in accordance with clinical laboratory standards. Additionally, analytical and clinical recoveries were assessed to investigate comparability between available joint fluid types and existing calibrators prepared in urine to demonstrate acceptability of a matrix-substitution design. 124 de-identified joint fluid samples submitted for unrelat

SUBMITTER: Haglock-Adler CJ 

PROVIDER: S-EPMC11322749 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature