Development of a prototype blood fractionation cartridge for plasma analysis by paper spray mass spectrometry.

ABSTRACT: Drug monitoring of biofluids is often time consuming and prohibitively expensive. Analysis of dried blood spots offers advantages, such as reduced sample volume, but depends on extensive sample preparation and the presence of a trained lab technician. Paper spray mass spectrometry allows rapid analysis of small molecules from blood spots with minimal sample preparation, however, plasma is often the preferred matrix for bioanalysis. Plasma spots can be analyzed by paper spray MS, but a centrifugation step to isolate the plasma is required. We demonstrate here the development of a paper spray cartridge containing a plasma fractionation membrane to perform automatic on-cartridge plasma fractionation from whole blood samples. Three commercially available blood fractionation membranes were eval

SUBMITTER: Bills BJ 

PROVIDER: S-EPMC11322750 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature