Chirality and pH Influence the Self-Assembly of Antimicrobial Lipopeptides with Diverse Nanostructures.

ABSTRACT: Chirality plays a crucial role in the self-assembly of biomolecules in nature. Peptides show chirality-dependent conformation and self-assembly. Lipidation of peptides occurs in vivo and has recently been exploited in designed conjugates to drive self-assembly and enhance bioactivity. Here, a library of pH-responsive homochiral and heterochiral lipidated tripeptides has been designed. The designed lipopeptides comprise homochiral C₁₆-YKK or C₁₆-WKK (where all the amino acids are l-isomers), and two heterochiral conjugates C₁₆-Ykk and C₁₆-Wkk (where the two lysines are d-isomers). The self-assembly of all the synthesized lipopeptides in aqueous solution was examined using a combination of spectroscopic methods along with cryogenic-transmission ele

SUBMITTER: Adak A 

PROVIDER: S-EPMC11337160 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature