Age added to MELD or ACLF predicts survival in patients with alcohol-associated hepatitis declined for liver transplantation.

ABSTRACT:

Background

Severe alcohol-associated hepatitis (AH) that is nonresponsive to corticosteroids is associated with high mortality, particularly with concomitant acute-on-chronic liver failure (ACLF). Most patients will not be candidates for liver transplantation (LT) and their outcomes are largely unknown. Our aim was to determine the outcomes of these declined candidates and to derive practical prediction models for transplant-free survival applicable at the time of the waitlist decision.

Methods

We analyzed a database of patients with severe AH who were hospitalized at a LT center from January 2012 to July 2021, using the National Death Index for those lacking follow-up. Clinical variables were analyzed based on the endpoints of mortality at 30, 60, 90, and 180 days. Logistic

SUBMITTER: Rutledge SM 

PROVIDER: S-EPMC11340926 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature