Gene signature-MELD score and alcohol relapse determine long-term prognosis of patients with severe alcoholic hepatitis.

ABSTRACT:

Background

The gene-signature-model for end stage liver disease (gs-MELD) score has been shown to be a strong predictor of 6-month survival in severe alcoholic hepatitis (AH). Currently, only a few studies have evaluated the long-term prognosis of patients with severe AH.

Aim

To assess the prognostic value of the gs-MELD score at 5 years in patients with severe AH.

Methods

Forty-eight consecutive patients with AH (25 males, median age 52 years [95% IC: 48-56]) were included.

Results

The median gs-MELD score was 2.6 (95% CI: 2.2-3.0). According to the gs-MELD score, 22 patients (46%) were considered to have a poor prognosis. During a median follow-up of 29 months (95% CI: 4-43), 19 patients (40%) were abstinent and 24 patients (50%) died. At 5 years, rates of su

SUBMITTER: Deltenre P 

PROVIDER: S-EPMC7056530 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature