Comparison of two viscoelastic testing devices in a porcine model of surgery, hemorrhage and resuscitation.

ABSTRACT:

Introduction

Viscoelastic hemostatic assays (VHA) are integral in contemporary hemostatic resuscitation, offering insights into clot formation, firmness, and lysis for rapid diagnosis and targeted therapy. Large animal models, particularly swine, provide anatomical and physiological analogies for coagulation research. Despite the growing use of VHAs, the ClotPro^® device's applicability in porcine models remains unexplored. This study investigates ClotPro^® in a porcine model of abdominal surgery, severe hemorrhage, and resuscitation, comparing it with the established ROTEM^® delta system.

Methods

Twenty-seven healthy pigs underwent abdominal surgery, hemorrhage and resuscitation. ClotPro^® and ROTEM^® were used to assess vis

SUBMITTER: Gruneberg D 

PROVIDER: S-EPMC11347288 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature