The Emergence and Impact of the M1_UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand.

ABSTRACT: M1_UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1_UK is now the dominant invasive emm1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A Streptococcus pharyngitis in children could reduce invasive disease.

SUBMITTER: Vesty A 

PROVIDER: S-EPMC11350281 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature