Characterization of emergent toxigenic M1_UK <i>Streptococcus pyogenes</i> and associated sublineages.

ABSTRACT: Streptococcus pyogenes genotype emm1 is a successful, globally distributed epidemic clone that is regarded as inherently virulent. An emm1 sublineage, M1_UK, that produces increased levels of SpeA toxin was associated with increased scarlet fever and invasive infections in England in 2015/2016. Defined by 27 SNPs in the core genome, M1_UK is now dominant in England. To more fully characterize M1_UK, we undertook comparative transcriptomic and proteomic analyses of M1_UK and contemporary non-M1_UK emm1 strains (M1_global). Just seven genes were differentially expressed by M1_UK compared with contemporary M1_global strains. In addition to speA, five genes in the operon that incl

SUBMITTER: Li HK 

PROVIDER: S-EPMC10210942 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature