Genome-wide association study of susceptibility to Pseudomonas aeruginosa infection in cystic fibrosis.

ABSTRACT:

Background

Pseudomonas aeruginosa is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing CFTR (CF transmembrane conductance regulator) variations contribute ∼85% of the variation in chronic P. aeruginosa infection age in CF according to twin studies, but the susceptibility loci remain unknown. Our objective is to advance understanding of the genetic basis of host susceptibility to P. aeruginosa infection.

Materials and methods

We conducted a genome-wide association study of chronic P. aeruginosa infection age in 1037 Canadians with CF. We subsequently assessed the genetic correlation between chronic P. aeruginosa infection age and lung function through polygeni

SUBMITTER: Lin B 

PROVIDER: S-EPMC11540985 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature