Domain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.

ABSTRACT:

Objectives

We investigated the domain-specific patterns of the association of segmental brain volume and white matter signal abnormality (WMSA) volume with longitudinal changes in cognitive function.

Methods

Participants from an institutional health check-up program who were aged >50 years, did not have a confirmed central nervous system disorder and underwent baseline and follow-up evaluations for cognitive function and brain MRI with an interval of at least 1 year were included. Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K) assessment battery. Performance changes in each cognitive domain were analyzed for associations with serial data of segmental brain volume and WMSA volume.

Results

A

SUBMITTER: Lee WJ 

PROVIDER: S-EPMC11904571 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature