A network of transcriptionally coordinated functional modules in Saccharomyces cerevisiae.

ABSTRACT: Recent computational and experimental work suggests that functional modules underlie much of cellular physiology and are a useful unit of cellular organization from the perspective of systems biology. Because interactions among modules can give rise to higher-level properties that are essential to cellular function, a complete knowledge of these interactions is necessary for future work in systems biology, including in silico modeling and metabolic engineering. Here we present a computational method for the systematic identification and analysis of functional modules whose activity is coordinated at the level of transcription. We applied this method, Search for Pairwise Interactions (SPIN), to obtain a global view of functional module connectivity in Saccharomyces cerevisiae and to provide

SUBMITTER: Petti AA 

PROVIDER: S-EPMC1199545 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature