Hypothyroidism and the risk of liver-related events in patients with metabolic dysfunction-associated steatotic liver disease.

ABSTRACT:

Background/aims

Previous studies suggest that hypothyroidism is associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and its histological severity, but clinical outcome data are largely lacking. We aimed to study the impact of hypothyroidism on liver-related events (LREs).

Methods

Patients with MASLD were identified from a territory-wide registry in Hong Kong during 2000-2024. Thyroid status was determined using diagnosis codes and thyroid function tests. The primary outcome, LRE, was defined as a composite of hepatic decompensation, hepatocellular carcinoma, liver transplantation, and liver-related death.

Results

A total of 20,478 patients with MASLD were included in the final analysis (mean age 56.4±13.2 years; 43.9% male). At baseline, 1

SUBMITTER: Jin X 

PROVIDER: S-EPMC12835781 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature