Epigenomic subtypes and prognostic methylation signatures in clear cell renal cell carcinoma.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) is characterized by marked epigenetic dysregulation, contributing to aberrant gene expression and tumor progression. To expand current knowledge on genome-wide methylation patterns in ccRCC, we performed Methylated DNA Immunoprecipitation sequencing (MeDIP-seq) on tumor samples from 116 ccRCC patients and 34 adjacent normal renal tissues. We identified differentially methylated regions (DMRs) and integrated these findings with genome-wide copy number alterations.

Results

ccRCC tumors exhibited global hypomethylation combined with focal hypermethylation, particularly within intergenic and repetitive genomic regions. Unsupervised clustering revealed three distinct subtypes, including one subtype characterized by chromosomal in

SUBMITTER: Iisager L 

PROVIDER: S-EPMC12908367 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature