Dataset Information
Causal effects of serum testosterone on septic shock mortality: a Mendelian randomization study.
Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi N
PROVIDER: S-EPMC12910909 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
Causal effects of serum testosterone on septic shock mortality: a Mendelian randomization study.
Critical care (London, England) 20260123 1
BACKGROUND: Sex hormones, particularly testosterone, modulate immune function during critical illness, and patients with septic shock frequently exhibit hypotestosteronemia. However, the causal relationship between testosterone and outcomes remains unclear owing to the confounding effects of illness-related changes in hormone levels during acute illness. METHODS: We investigated 469 patients with septic shock in multicenter ICUs using a testosterone polygenic score (PGS) derived from genome-wide ...[more]