Ontology highlight
ABSTRACT:
SUBMITTER: Pipkin ME
PROVIDER: S-EPMC1388096 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Pipkin Matthew E ME Lichtenheld Mathias G MG
Nucleic acids research 20060301 4
The study of eukaryotic gene transcription depends on methods to discover distal cis-acting control sequences. Comparative bioinformatics is one powerful strategy to reveal these domains, but still requires conventional wet-bench techniques to elucidate their specificity and function. The DNase I hypersensitivity assay (DHA) is also a method to identify regulatory domains, but can also suggest their function. Technically however, the classical DHA is constrained to mapping gene loci in small inc ...[more]