Quantitative assessment of relationship between sequence similarity and function similarity.

ABSTRACT:

Background

Comparative sequence analysis is considered as the first step towards annotating new proteins in genome annotation. However, sequence comparison may lead to creation and propagation of function assignment errors. Thus, it is important to perform a thorough analysis for the quality of sequence-based function assignment using large-scale data in a systematic way.

Results

We present an analysis of the relationship between sequence similarity and function similarity for the proteins in four model organisms, i.e., Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorrhabditis elegans, and Drosophila melanogaster. Using a measure of functional similarity based on the three categories of Gene Ontology (GO) classifications (biological process, molecular function, and cel

SUBMITTER: Joshi T 

PROVIDER: S-EPMC1949826 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature