Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.

ABSTRACT:

Rationale

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.

Objectives

To investigate whether deficiency of cat S alters the course of hyperoxia-induced neonatal lung injury in mice.

Methods

Newborn wild-type and cat S-deficient mice were exposed to 80% oxygen for 14 days. Histologic and morphometric analysis were performed and bronchoalveolar lavage protein and cells were analyzed. Lung elastin was assessed by real-time p

SUBMITTER: Hirakawa H 

PROVIDER: S-EPMC2020827 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature