A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer.

ABSTRACT:

Background

The purpose of this study was to evaluate the role of osteoprotegerin gene (OPG) polymorphisms as genetic modifiers in the etiology of prostate cancer (PCa) and disease progression.

Methods

Three hundred and sixty one patients with PCa and 195 normal controls were enrolled in the study, and two genetic polymorphisms, 149 T/C and 950 T/C in the putative promoter region of OPG, were genotyped.

Results

There was no significant difference in the genotype frequencies between PCa patients and controls (P = 0.939 and 0.294 for 149 T/C and 950 T/C polymorphisms, respectively). However, those patients with TC and TT genotypes in the 950 T/C polymorphism had a significantly increased risk of extraprostatic (age-adjusted odds ratio; aOR = 1.74 and 2.03 for TC and TT g

SUBMITTER: Narita N 

PROVIDER: S-EPMC2527333 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature