Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.

ABSTRACT:

Context

Experimental studies in GH-deficient patients and in healthy subjects receiving somatostatin-infusion suggest that GH is an important regulator of substrate metabolism during fasting. These models may not adequately reflect the selective effects of GH, and GH receptor (GHR) blockade offers a new model to define the metabolic role of GH.

Objective

The aim of this study was to investigate the impact of GHR blockade on substrate metabolism and insulin sensitivity during fasting.

Design

We conducted a randomized, placebo-controlled, crossover study in 10 healthy young men.

Intervention

After 36 h of fasting with saline or pegvisomant (GHR blockade), the subjects were studied during a 4-h basal period and 2.5-h hyperinsulinemic euglycemic clamp.

Main outc

SUBMITTER: Moller L 

PROVIDER: S-EPMC2775657 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature