Ontology highlight
ABSTRACT:
SUBMITTER: Terret ME
PROVIDER: S-EPMC2777716 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Nature 20091101 7270
Cohesin not only links sister chromatids but also inhibits the transcriptional machinery's interaction with and movement along chromatin. In contrast, replication forks must traverse such cohesin-associated obstructions to duplicate the entire genome in S phase. How this occurs is unknown. Through single-molecule analysis, we demonstrate that the replication factor C (RFC)-CTF18 clamp loader (RFC(CTF18)) controls the velocity, spacing and restart activity of replication forks in human cells and ...[more]