Dynamics and control of the central carbon metabolism in hepatoma cells.

ABSTRACT:

Background

The liver plays a major role in metabolism and performs a number of vital functions in the body. Therefore, the determination of hepatic metabolite dynamics and the analysis of the control of the respective biochemical pathways are of great pharmacological and medical importance. Extra- and intracellular time-series data from stimulus-response experiments are gaining in importance in the identification of in vivo metabolite dynamics, while dynamic network models are excellent tools for analyzing complex metabolic control patterns. This is the first study that has been undertaken on the data-driven identification of a dynamic liver central carbon metabolism model and its application in the analysis of the distribution of metabolic control in hepatoma cells.

Results

SUBMITTER: Maier K 

PROVIDER: S-EPMC2874527 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature