Ontology highlight
ABSTRACT:
SUBMITTER: Farci P
PROVIDER: S-EPMC2889296 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20100426 19
Hepatitis B virus (HBV)-associated acute liver failure (ALF) is a dramatic clinical syndrome due to a sudden loss of hepatic cells leading to multiorgan failure. The mechanisms whereby HBV induces ALF are unknown. Here, we show that liver tissue collected at the time of liver transplantation in two patients with HBV-associated ALF is characterized by an overwhelming B cell response apparently centered in the liver with massive accumulation of plasma cells secreting IgG and IgM, accompanied by co ...[more]