Ontology highlight
ABSTRACT:
SUBMITTER: Tzartos JS
PROVIDER: S-EPMC3032888 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Tzartos John S JS Craner Matthew J MJ Friese Manuel A MA Jakobsen Karen B KB Newcombe Jia J Esiri Margaret M MM Fugger Lars L
The American journal of pathology 20110201 2
IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21(+) ...[more]