Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.

ABSTRACT:

Objectives

To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes.

Design

Association study of AD and CLU, PICALM, CR1, and APOE genotypes.

Setting

Academic research institutions in the United States, Canada, and Israel.

Participants

Seven thousand seventy cases with AD, 3055 with autopsies, and 8169 elderly cognitively normal controls, 1092 with autopsies, from 12 different studies, including white, African American, Israeli-Arab, and Caribbean Hispanic individuals.

Results

Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR,

SUBMITTER: Jun G 

PROVIDER: S-EPMC3048805 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature