Regulation of gene expression in human tendinopathy.

ABSTRACT:

Background

Chronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure, yet little is known about the molecular mechanisms leading to tendinopathy.

Methods

We have used histological evaluation and molecular profiling to determine gene expression changes in 23 human patients undergoing surgical procedures for the treatment of chronic tendinopathy.

Results

Diseased tendons exhibit altered extracellular matrix, fiber disorientation, increased cellular content and vasculature, and the absence of inflammatory cells. Global gene expression profiling identified 983 transcripts with significantly different expression patterns in the diseas

SUBMITTER: Jelinsky SA 

PROVIDER: S-EPMC3095578 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature