Sigma-2 receptor as potential indicator of stem cell differentiation.
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ABSTRACT:
SUBMITTER: Haller JL
PROVIDER: S-EPMC3164741 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Sigma-2 receptor as potential indicator of stem cell differentiation.
Haller Jodi L JL Panyutin Irina I Chaudhry Aneeka A Zeng Chenbo C Mach Robert H RH Frank Joseph A JA
Molecular imaging and biology 20120601 3
<h4>Purpose</h4>The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy.<h4>Procedures</h4>We employed the fluorescently labeled σ(2) receptor probe, SW120, to evaluate σ(2) receptor expression in human stem cells (SC), including: bone marrow stromal, neural progenitor, amniotic fluid ...[more]
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