Alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2.

ABSTRACT:

Purpose

Common polymorphisms in the N-acetyltransferase-2 (NAT2) metabolic enzyme determine slow or rapid acetylator phenotypes. We investigated the effects of alcohol, smoking, and caffeine on fecundability, and determined whether the effects were modified by NAT2.

Methods

Three NAT2 polymorphisms were genotyped in 319 women office workers participating in a prospective pregnancy study (1990-1994). Women were ages 20-41 and at risk for pregnancy. Discrete-time survival analysis was used to determine the effects of alcohol, smoking, and caffeine on fecundability and evaluate effect modification by NAT2.

Results

We followed 319 women (161 slow acetylators, 158 rapid) for an average of 8 menstrual cycles, resulting in 124 pregnancies. There was no effect of caffeine on

SUBMITTER: Taylor KC 

PROVIDER: S-EPMC3203540 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature